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Open Access
Peer-reviewed
Research Article
- Emmanuel A. Burdmann ,
- Maria Lúcia Lebrão †,
- Yeda A. O. Duarte ,
- Dirce M. T. Zanetta
Aging and decreased glomerular filtration rate: An elderly population-based study
- Regina C. R. M. Abdulkader,
- Emmanuel A. Burdmann,
- Maria Lúcia Lebrão,
- Yeda A. O. Duarte,
- Dirce M. T. Zanetta
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- Published: December 19, 2017
- //doi.org/10.1371/journal.pone.0189935
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Abstract
Background
Although a reduced glomerular filtration rate [GFR] in old people has been attributed to physiologic aging, it may be associated with kidney disease or superimposed comorbidities. This study aims to assess the prevalence of decreased GFR in a geriatric population in a developing country and its prevalence in the absence of simultaneous diseases.
Study design and methods
This is a cross-sectional study of data from the Saúde, Bem-Estar e Envelhecimento cohort study [SABE study[Health, Well-Being and Aging]], a multiple cohorts study. A multistage cluster sample composed of 1,253 individuals representative of 1,249,388 inhabitants of São Paulo city aged ≥60 years in 2010 was analyzed. The participants answered a survey on socio-demographic factors and health, had blood pressure measured and urine and blood samples collected. GFR was estimated and defined as decreased when 0.20 g/g.
Results
The prevalence of GFR